087 Molecular and cellular mechanisms of tolerogenic signature induction in CD4+ T cells by apoptotic cells
نویسندگان
چکیده
منابع مشابه
Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells
Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral blood naïve CD4+ T cells were co-cultured with ASCs derived from breast cancer or normal breast ...
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Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: Dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...
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Background: Polycystic ovary syndrome (PCOS) is considered as the most common cause of female infertility that affects 4-10% of women in the reproductive age. Previous studies have shown the role of a balanced immune response in a successful pregnancy and fertility. Objective: To investigate the T helper cells type 1 (Th1) /Th2/Th17/Treg paradigms in peripheral blood of infertile PCOS compared ...
متن کاملPharmacological induction of tolerogenic dendritic cells and regulatory T cells.
Immunosuppressive and anti-inflammatory agents are able to generate tolerogenic DCs, leading, in some cases, to induction or enhancement of regulatory T cells with suppressive activity. This novel mechanism of action, shared by several immunosuppressive and anti-inflammatory agents, is becoming firmly established and contributes to explain their functional properties. The possibility to manipul...
متن کاملApoptotic Cell-induced Tolerogenic Dendritic Cells Facilitate Development of CD4+ and CD8+ Regulatory T cell Subsets
Objective: Dendritic cells (DCs) play an important role in regulating T cell-mediated immune responses; however, the mechanisms of DC-mediated immune responses have not been fully elucidated. Regulatory T cells (Tregs) including CD4+ and CD8+ Tregs play an essential role in induction of immune tolerance in vivo. It is unclear how DCs regulate development of Tregs. Our objective is to observe wh...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.03.163